F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell.

Product information

CAS Number: 36098-33-6

Molecular Weight: 362.21

Formula: C16H15IN2

Chemical Name: 4-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methylpyridin-1-ium iodide

Smiles: [I-].C[N+]1C=CC(/C=C/C2=CNC3=CC=CC=C23)=CC=1

InChiKey: UURAKYSOOXPORG-UHFFFAOYSA-N

InChi: InChI=1S/C16H14N2.HI/c1-18-10-8-13(9-11-18)6-7-14-12-17-16-5-3-2-4-15(14)16;/h2-12H,1H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 31 mg/mL (85.59 mM) Ethanol : 1 mg/mL (2.76 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines. F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells.

References:

1. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42.
2. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36.

Products are for research use only. Not for human use.