MB-VC-MGBA is a drug-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC.

Product information

CAS Number: 932744-62-2

Molecular Weight: 1101.64

Formula: C56H65ClN12O10

Chemical Name: (1S)-3-(5-{4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-({2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanamido]ethyl}amino)-3-methylbutanamido]pentanamido]benzamido}-1H-indole-2-carbonyl)-1-(chloromethyl)-1H,2H,3H-benzo[e]indol-5-yl 4-methylpiperazine-1-carboxylate

Smiles: CN1CCN(CC1)C(=O)OC1=CC2=C([C@H](CCl)CN2C(=O)C2=CC3=CC(=CC=C3N2)NC(=O)C2C=CC(=CC=2)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NCCNC(=O)CCCN2C(=O)C=CC2=O)C(C)C)C2=CC=CC=C21

InChiKey: LWUVZRWVARAEMO-MUYWJSLASA-N

InChi: InChI=1S/C56H65ClN12O10/c1-33(2)50(60-22-21-59-46(70)11-7-23-68-47(71)18-19-48(68)72)53(75)65-42(10-6-20-61-55(58)77)52(74)62-37-14-12-34(13-15-37)51(73)63-38-16-17-41-35(28-38)29-43(64-41)54(76)69-32-36(31-57)49-40-9-5-4-8-39(40)45(30-44(49)69)79-56(78)67-26-24-66(3)25-27-67/h4-5,8-9,12-19,28-30,33,36,42,50,60,64H,6-7,10-11,20-27,31-32H2,1-3H3,(H,59,70)(H,62,74)(H,63,73)(H,65,75)(H3,58,61,77)/t36-,42+,50+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.