Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway.

Product information

CAS Number: 13395-02-3

Molecular Weight: 293.27

Formula: C17H11NO4

Synonym:

Aristololactam

Aristolactam

Chemical Name: 14-methoxy-3, 5-dioxa-10-azapentacyclo[9.7.1.0, .0, .0, ]nonadeca-1(18), 2(6), 7, 11(19), 12, 14, 16-heptaen-9-one

Smiles: COC1=CC=CC2C3=C4C(=CC=21)NC(=O)C4=CC1OCOC=13

InChiKey: MXOKGWUJNGEKBH-UHFFFAOYSA-N

InChi: InChI=1S/C17H11NO4/c1-20-12-4-2-3-8-9(12)5-11-14-10(17(19)18-11)6-13-16(15(8)14)22-7-21-13/h2-6H,7H2,1H3,(H,18,19)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Li J, et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7.

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