SULT2A1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91300-50, BS91300-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q06520(Human) P52843(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC, IF, IHC, FC

All Applications: WB:1:500-1:1,000
ICC:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100

Background: The soluble sulfotransferases contribute to the elimination of xenobiotics, the activation of procarcinogens and the regulation of hormones. Members of the three groups comprising this superfamily show selectivity to certain substrate compounds. SULT1 sulfotransferases exhibit N-sulfating activities of carcinogenic heterocyclic amines, and are selective toward phenols, whereas SULT2 enzymes prefer hydroxysteroids and SULT3 family members are selective for N-substituted aryl and alicyclic compounds. SULT2A1 catalyzes the sulfonation of procarcinogen xenobiotics, hydroxysteroids and bile acids, and is highly expressed in adrenal and liver tissues. SULT2A1 plays a role in hepatic cholesterol homeostasis. SULT2B1 consists of two isoforms, SULT2B1a and SULT2B1b, which are transcribed from the same gene by alternative splicing of their first exons. Both isoforms are highly selective for the sulphation of 3b-hydroxysteroids such as pregnenolone, epiandrosterone, DHEA and androstenediol. SULT2B1b is expressed in prostate, skin, placenta and lung.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SULT2A1 polyclonal antibody detects endogenous levels of SULT2A1 protein.

Bioworld Molecular Weight: 34 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SULT2A1 on mouse kidney tissue lysate using anti-SULT2A1 antibody at 1/1,000 dilution., ICC staining SULT2A1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: DHEA-ST, HST, ST2A1, SULT2A1, HST, STD, Alcohol/hydroxysteroid sulfotransferase, Bile salt sulfotranasferase 2A1, Bile salt sulfotransferase, Dehydroepiandrosterone sulfotransferase, DHEA ST, DHEA sulfotranasferase, DHEA-ST, DHEAS, EC 2.8.2.14, Hst, hSTa, Hydroxysteroid sulfotransferase, ST2, ST2A1, ST2A1, ST2A3, STD, sulfotranasferase, dehydroepiandrosterone-preferring, Sulfotransferase 2A1, Sulfotransferase family 2A, dehydroepiandrosterone-preferring, member 1, Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA) preferring member 1, Sult2a1,

Immunogen: Recombinant protein within human SULT2A1 aa 100 to the C-terminus.

Conjugate: Unconjugated

Modification: Unmodified