Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.

Product information

CAS Number: 526-08-9

Molecular Weight: 314.36

Formula: C15H14N4O2S

Chemical Name: 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzene-1-sulfonamide

Smiles: NC1C=CC(=CC=1)S(=O)(=O)NC1=CC=NN1C1C=CC=CC=1

InChiKey: QWCJHSGMANYXCW-UHFFFAOYSA-N

InChi: InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 100 mg/mL (318.11 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Sai Y, et al. Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450[J]. Xenobiotica, 2000, 30(4):327-343.
2. Fleming I, et al. Endothelium-Derived Hyperpolarizing Factor Synthase (Cytochrome P450 2C9) Is a Functionally Significant Source of Reactive Oxygen Species in Coronary Arteries[J]. Circulation Research, 2001, 88(1):44.

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