Chelidonine is an isoquinoline alkaloid isolated from Chelidonium majus L., causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, with anticancer and antiviral activity.

Product information

CAS Number: 476-32-4

Molecular Weight: 353.37

Formula: C20H19NO5

Chemical Name: (1S, 12S, 13R)-24-methyl-5, 7, 18, 20-tetraoxa-24-azahexacyclo[11.11.0.0, .0, .0, .0, ]tetracosa-2(10), 3, 8, 14(22), 15, 17(21)-hexaen-12-ol

Smiles: CN1CC2=C3OCOC3=CC=C2[C@H]2[C@@H](O)CC3=CC4OCOC=4C=C3[C@@H]12

InChiKey: GHKISGDRQRSCII-ZOCIIQOWSA-N

InChi: InChI=1S/C20H19NO5/c1-21-7-13-11(2-3-15-20(13)26-9-23-15)18-14(22)4-10-5-16-17(25-8-24-16)6-12(10)19(18)21/h2-3,5-6,14,18-19,22H,4,7-9H2,1H3/t14-,18-,19+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Lee YK, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019 May 26;2019:6318179.

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