Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 86520-52-7

Molecular Weight: 175.19

Formula: C6H13N3O3

Chemical Name: 2-[2-(2-azidoethoxy)ethoxy]ethan-1-ol

Smiles: [N-]=[N+]=NCCOCCOCCO

InChiKey: PMNIHDBMMDOUPD-UHFFFAOYSA-N

InChi: InChI=1S/C6H13N3O3/c7-9-8-1-3-11-5-6-12-4-2-10/h10H,1-6H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (570.81 mM; Need ultrasonic) H2O : 50 mg/mL (285.40 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

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