US Marshal Teddy Daniels has come to Shutter Island, home of Ashecliffe Hospital for the Criminally Insane, to find an escaped murderer named Rachel Solando. As a killer hurricane bears down on the island, the investigation deepens and the questions mount.

How has a barefoot woman escaped from a locked room? Who is leaving them clues in the form of cryptic codes? And what really goes on in Ward C? The closer Teddy gets to the truth, the more elusive it becomes. And the more he begins to believe that he may never leave Shutter Island. Because someone is trying to drive him insane..